Format

Send to

Choose Destination
See comment in PubMed Commons below
Physiol Res. 2006;55(2):195-204. Epub 2005 May 24.

Red blood cell triiodothyronine uptake as membrane parameter of depression.

Author information

1
Department of Psychiatry, First Faculty of Medicine, Charles University, Ke Karlovu 11, 128 01, Prague 2, Czech Republic. lucie_starkova@yahoo.com

Abstract

We tested the hypothesis considering the role of hypothalamic-pituitary-thyroid axis (HPT), L-triiodothyronine (L-T3) uptake into erythrocytes, and the role of membrane lipids in the development and treatment of affective disorders. Changes in kinetic parameters (V(max), maximal velocity and K(M), apparent Michaelis constant) of L-T3 uptake into red blood cells (RBCs) and changes in membrane fluidity in a group of 24 patients with major depression were measured before treatment and after 1 month of treatment with citalopram. Parameters V(max) and K(M), as well as membrane microviscosity, were significantly increased in depressed patients both before and after treatment in comparison with healthy subjects. We concluded that the function of the membrane transporter for L-T3 in RBC is changed in depression. This change is probably connected with alteration of membrane fluidity and/or transporter-lipid interactions. We did not find any normalization of the measured parameters after 1 month of treatment. The results show the importance of composition and physical properties of the lipid bilayer for transmembrane transport of L-T3 and support the hypothesis that the HPT axis is in depression.

PMID:
15910168
[Indexed for MEDLINE]
Free full text
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Institute of Physiology, Academy of Sciences of the Czech Republic, Prague
    Loading ...
    Support Center