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Annu Rev Immunol. 1992;10:333-58.

Cellular basis of skin allograft rejection: an in vivo model of immune-mediated tissue destruction.

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Cytokine Biology Division, Food and Drug Administration, Bethesda, Maryland 20892.


Rejection of transplanted tissue allografts results from T-cell recognition of histocompatibility antigens expressed by cells of the donor graft. This review focuses on the phenotype, specificity, and function of the T cells mediating rejection responses against skin allografts, and on the immune mechanisms by which host T cells are either activated or rendered non-responsive by cellular populations within the graft. We review the cellular basis for rejection responses across limited class-I and class-II major histocompatibility differences, as well as the specificity of the rejection response itself.

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