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Nat Immunol. 2005 Jun;6(6):551-7.

Mammalian defensins in the antimicrobial immune response.

Author information

  • 1Department of Pathology and Laboratory Medicine, and Center for Immunology, School of Medicine, University of California, Irvine, California 92697, USA. meselste@uci.edu <meselste@uci.edu>

Abstract

Defensins are peptidic components of the innate immune system of plants and animals. In mammals, defensins have evolved to have a central function in the host defense properties of granulocytic leukocytes, mucosal surfaces, skin and other epithelia. This review focuses on the biological functions of three structural subgroups of mammalian defensins and the evidence for their involvement as effectors of antimicrobial innate immunity.

PMID:
15908936
DOI:
10.1038/ni1206
[PubMed - indexed for MEDLINE]
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