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Cancer Biol Ther. 2005 May;4(5):506-8. Epub 2005 May 5.

Tumor suppressor activities of the Fbw7 E3 ubiquitin ligase receptor.

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Department of Animal Biology, University of Pennsylvania, Philadelphia, PA 19104-6046, USA.


The F-box protein Fbw7/Sel-10/hCdc4/Ago, which is known to regulate ubiquitination and degradation of numerous important regulators of cell division and death including Notch, cyclin E, c-Jun and c-Myc, has been recently rediscovered as a p53-dependent tumor suppressor. Delineation of the mechanisms of Fbw7 anti-oncogenic activities and of its inactivation in human cancers is expected to gain an important insight into tumorigenesis.

[Indexed for MEDLINE]

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