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Infect Immun. 2005 Jun;73(6):3790-3.

Entamoeba histolytica-secreted products degrade colonic mucin oligosaccharides.

Author information

1
Institute of Parasitology, McGill University, 21,111 Lakeshore Road, Ste. Anne de Bellevue, Quebec, Canada H9X 3V9.

Abstract

Degradation of the mucus layer by Entamoeba histolytica is a prerequisite for invasion of the colonic mucosa. In this study, we demonstrate that amoeba-secreted products degrade (3)H-labeled and native colonic mucin oligosaccharides independently of proteolytic activity. We conclude that E. histolytica degrades mucin oligosaccharides, which may facilitate parasite invasion of the colon.

PMID:
15908414
PMCID:
PMC1111884
DOI:
10.1128/IAI.73.6.3790-3793.2005
[Indexed for MEDLINE]
Free PMC Article

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