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Curr Opin Pharmacol. 2005 Jun;5(3):232-7.

Apoptosis as a therapeutic target for the treatment of lung disease.

Author information

1
Thoracic Medicine, National Heart and Lung Institute, Imperial College Medical School, Dovehouse Street, London SW3 6LY, UK. p.desouza@imperial.ac.uk

Abstract

It has been speculated that the destruction of lung tissue, associated with several acute and chronic diseases, is in part mediated through apoptosis or programmed cell death. Thus, it has been shown that both increased endothelial/epithelial cell apoptosis and decreased cell death of inflammatory cells are associated with acute lung injury/acute respiratory distress syndrome, chronic obstructive pulmonary disease, asthma and pulmonary fibrosis. In the light of these observations, it might be possible to use apoptosis modulation as a novel therapeutic approach to the treatment of lung disease.

PMID:
15907908
DOI:
10.1016/j.coph.2005.01.012
[Indexed for MEDLINE]

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