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FEBS Lett. 2005 May 23;579(13):2833-41. Epub 2005 Apr 25.

Immune cell-induced synthesis of NO and reactive oxygen species in lymphoma cells causes their death by apoptosis.

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Department of Biochemistry, University of Cambridge, UK.


Induction of apoptosis in a lymphoma cell line using immune cell-conditioned medium, etoposide or an nitric oxide (NO) donor, resulted in the production of reactive oxygen species (ROS). Agents that inhibited NO production or scavenged ROS or species formed by reaction of NO with ROS, protected the cells from apoptosis. These data support the suggestion that immune rejection of an immunogenic derivative of this lymphoma in vivo involves the induced synthesis of both NO and ROS by the tumour cells.

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