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Antimicrob Agents Chemother. 1992 Jan;36(1):202-5.

The separated enantiomers of 2'-deoxy-3'-thiacytidine (BCH 189) both inhibit human immunodeficiency virus replication in vitro.

Author information

1
Department of Virology, Glaxo Group Research Ltd., Greenford, Middlesex, United Kingdom.

Abstract

Racemic 2'-deoxy-3'-thiacytidine (BCH 189) is a dideoxycytidine analog having a sulfur atom in place of the 3' carbon. The enantiomers of BCH 189 have been resolved and found to be equipotent in antiviral activity against human immunodeficiency virus types 1 and 2. However, the (-)-enantiomer (3TC) is considerably less cytotoxic than the (+)-enantiomer.

PMID:
1590690
PMCID:
PMC189255
DOI:
10.1128/aac.36.1.202
[Indexed for MEDLINE]
Free PMC Article

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