A functional polymorphism of the NFKB1 promoter is not associated with ulcerative colitis in a Spanish population

Inflamm Bowel Dis. 2005 Jun;11(6):576-9. doi: 10.1097/01.mib.0000161916.20007.76.

Abstract

Background: This study investigated the influence of the NFKB1-94ins/delATTG in the susceptibility/phenotype to ulcerative colitis.

Methods: We analyzed the distribution of -94ins/delATTG NFKB1 in 258 patients and 264 healthy controls from southern Spain by a polymerase chain reaction-fluorescent method.

Results: The genotype and allele frequencies of -94ins/delATTG did not significantly differ between patients and controls. In fact, the frequency of the -94delATTG allele was almost identical in both groups (34.8% and 35.4%, respectively), and the del/del genotype was underrepresented in UC patients (11.2% versus 14%). In addition, no association of this polymorphism was found with any of the clinical parameters analyzed.

Conclusion: These results suggest that the NFKB1 -94ins/delATTG gene variation, previously associated with UC susceptibility in North Americans, does not influence either susceptibility or phenotype of UC in the Spanish population.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Case-Control Studies
  • Colitis, Ulcerative / ethnology
  • Colitis, Ulcerative / etiology
  • Colitis, Ulcerative / genetics*
  • Female
  • Genetic Predisposition to Disease
  • Genotype
  • Humans
  • Male
  • Middle Aged
  • NF-kappa B p50 Subunit
  • Phenotype
  • Polymorphism, Genetic*
  • Spain
  • Transcription Factors / genetics*
  • Transcription Factors / physiology*

Substances

  • NF-kappa B p50 Subunit
  • NFKB1 protein, human
  • Transcription Factors