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Inflamm Bowel Dis. 2005 Jun;11(6):533-40.

Differential role of tumor necrosis factor receptors in TNBS colitis.

Author information

1
Division of Pediatric Gastroenterology and Nutrition, Department of Pediatrics, Washington University, St. Louis, Missouri, USA.

Abstract

BACKGROUND:

Tumor necrosis factor alpha (TNFalpha) plays a central role in the pathology of T helper 1-mediated colitis such as Crohn's disease; however, the role of its 2 receptors in mediating pathology has not been fully explored.

METHODS:

Trinitrobenzene sulfonic acid colitis was used to induce colitis in mice lacking each of the TNF receptors (TNFRs) and in wild-type mice. TNFR1-/- mice lost more weight, became hypothermic, and had increased mortality compared with wild-type C57Bl/6 mice. TNFR2-/- mice, however, lost less weight, had normal temperatures, and had improved survival.

RESULTS:

Despite the improved clinical outcomes in TNFR2-/- mice, TNFalpha levels were increased in these mice.

CONCLUSIONS:

TNFalpha signaling through TNFR1 is protective in the trinitrobenzene sulfonic acid mouse model of inflammatory bowel disease.

[Indexed for MEDLINE]

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