Send to

Choose Destination
Inflamm Bowel Dis. 2005 Jun;11(6):533-40.

Differential role of tumor necrosis factor receptors in TNBS colitis.

Author information

Division of Pediatric Gastroenterology and Nutrition, Department of Pediatrics, Washington University, St. Louis, Missouri, USA.



Tumor necrosis factor alpha (TNFalpha) plays a central role in the pathology of T helper 1-mediated colitis such as Crohn's disease; however, the role of its 2 receptors in mediating pathology has not been fully explored.


Trinitrobenzene sulfonic acid colitis was used to induce colitis in mice lacking each of the TNF receptors (TNFRs) and in wild-type mice. TNFR1-/- mice lost more weight, became hypothermic, and had increased mortality compared with wild-type C57Bl/6 mice. TNFR2-/- mice, however, lost less weight, had normal temperatures, and had improved survival.


Despite the improved clinical outcomes in TNFR2-/- mice, TNFalpha levels were increased in these mice.


TNFalpha signaling through TNFR1 is protective in the trinitrobenzene sulfonic acid mouse model of inflammatory bowel disease.

[Indexed for MEDLINE]

Supplemental Content

Loading ...
Support Center