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Bioinformatics. 2005 Aug 1;21(15):3320-1. Epub 2005 May 19.

Sequence to Structure (S2S): display, manipulate and interconnect RNA data from sequence to structure.

Author information

1
Institut de Biologie Moléculaire et Cellulaire du CNRS, UPR9002, Université Louis Pasteur, F-67084 Strasbourg, France. f.jossinet@ibmc.u-strasbg.fr

Abstract

SUMMARY:

Efficient RNA sequence manipulations (such as multiple alignments) need to be constrained by rules of RNA structure folding. The structural knowledge has increased dramatically in the last years with the accumulation of several large RNA structures similar to those of the bacterial ribosome subunits. However, no tool in the RNA community provides an easy way to link and integrate progress made at the sequence level using the available three-dimensional information. Sequence to Structure (S2S) proposes a framework in which an user can easily display, manipulate and interconnect heterogeneous RNA data, such as multiple sequence alignments, secondary and tertiary structures. S2S has been implemented using the Java language and has been developed and tested under UNIX systems, such as Linux and MacOSX.

AVAILABILITY:

S2S is available at http://bioinformatics.org/S2S/.

PMID:
15905274
DOI:
10.1093/bioinformatics/bti504
[Indexed for MEDLINE]
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