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Phys Rev Lett. 2005 Apr 1;94(12):128701. Epub 2005 Apr 1.

Cell fates as high-dimensional attractor states of a complex gene regulatory network.

Author information

1
Vascular Biology Program, Departments of Pathology & Surgery, Children's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA. sui.huang@childrens.harvard.edu
2
Harvard Med Sch, Boston, MA

Abstract

Cells in multicellular organisms switch between distinct cell fates, such as proliferation or differentiation into specialized cell types. Genome-wide gene regulatory networks govern this behavior. Theoretical studies of complex networks suggest that they can exhibit ordered (stable) dynamics, raising the possibility that cell fates may represent high-dimensional attractor states. We used gene expression profiling to show that trajectories of neutrophil differentiation converge to a common state from different directions of a 2773-dimensional gene expression state space, providing the first experimental evidence for a high-dimensional stable attractor that represents a distinct cellular phenotype.

PMID:
15903968
DOI:
10.1103/PhysRevLett.94.128701
[Indexed for MEDLINE]

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