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Phys Rev E Stat Nonlin Soft Matter Phys. 2005 Mar;71(3 Pt 1):031907. Epub 2005 Mar 18.

Nonequilibrium model for estimating parameters of deleterious mutations.

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Instituto Gulbenkian de Ciencia, Rua Quinta Grande, Oeiras, Portugal.


Deleterious mutations are of extreme evolutionary importance because, even though they are eliminated by natural selection, their continuous pressure creates a pool of variability in natural populations. They are of potential relevance for the existence of several features in evolution, such as sexual reproduction, and pose a risk to small asexual populations. Despite their extreme importance, the deleterious mutation rate and the effects of each mutation on fitness are poorly known quantities. Here we analyze a simple model that can be applied to simple experiments, in microorganisms, aiming at the quantification of these values.

[Indexed for MEDLINE]

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