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World J Gastroenterol. 2005 May 21;11(19):2949-52.

Expression of bcl-2 protein in chronic hepatitis C: effect of interferon alpha 2b with ribavirin therapy.

Author information

1
Department of Infectious Diseases, Medical University of Bialystok, Zurawia Str, 14, 15-540 Bialystok, Poland. apanasiuk@wp.pl

Abstract

AIM:

Mechanisms responsible for persistence of HCV infection and liver damage in chronic hepatitis C are not clear. Apoptosis is an important form of host immune response against viral infections. Anti-apoptotic protein bcl-2 expression on liver tissue as well as the influence of interferon alpha 2b (IFNalpha2b) and ribavirin (RBV) were analyzed in patients with chronic hepatitis C.

METHODS:

In 30 patients with chronic hepatitis C (responders--R and non-responders--NR) treated with IFNalpha2b+RBV, protein bcl-2 was determined in hepatocytes and in liver associated lymphocytes before and after the treatment.

RESULTS:

The treatment diminished bcl-2 protein accumulation in liver cells in patients with hepatitis C (P<0.05). Before and after the therapy, we detected bcl-2 protein in R in 87+/-15% and 83+/-20% of hepatocytes and in 28+/-18% and 26+/-10% of liver-associated lymphocytes, respectively. In NR, the values before treatment decreased from 94+/-32% to 88+/-21% of hepatocytes and 39+/-29% to 28+/-12% of lymphocytes with bcl-2 expression. There was no statistical correlation between bcl-2 expression on liver tissue with inflammatory activity, fibrosis and biochemical parameters before and after the treatment.

CONCLUSION:

IFNalpha2b+RBV treatment, by bcl-2 protein expression decrease, enables apoptosis of hepatocytes and associated liver lymphocytes, which in turn eliminate hepatitis C viruses.

PMID:
15902734
PMCID:
PMC4305665
[Indexed for MEDLINE]
Free PMC Article
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