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Am J Obstet Gynecol. 2005 May;192(5):1437-9.

Comparison of early-onset neonatal sepsis caused by Escherichia coli and group B Streptococcus.

Author information

1
Department of Obstetrics and Gynecology, Division of Maternal-Fetal Medicine, University of Miami School of Medicine, Fla, USA.

Abstract

OBJECTIVE:

The purpose of this study was to compare maternal characteristics and neonatal morbidity and mortality rates that are associated with early-onset neonatal sepsis that is caused by group B Streptococcus and Escherichia coli.

STUDY DESIGN:

This was a retrospective review of newborn infants with a positive blood culture (and/or cerebrospinal fluid) that was positive for either E coli or group B Streptococcus during the first week of life. Data were abstracted from maternal and neonatal medical records.

RESULTS:

Among 28,659 deliveries during the study period, 102 episodes of early-onset neonatal sepsis were identified, 61 of which were caused by group B Streptococcus and 41 of which were caused by E coli. E coli sepsis cases had a lower birth weight, a higher percentage with 5-minute Apgar score <7, and a longer stay in the hospital neonatal intensive care unit and required mechanical ventilation more frequently. Death after early-onset neonatal sepsis with E coli was also more frequent.

CONCLUSION:

Early-onset sepsis with E coli is associated with more morbidity and a higher mortality rate compared with early-onset group B Streptococcus.

PMID:
15902130
DOI:
10.1016/j.ajog.2004.12.031
[Indexed for MEDLINE]

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