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Clin Pharmacol Ther. 2005 May;77(5):341-52.

Cytochrome P450 2C8: substrates, inhibitors, pharmacogenetics, and clinical relevance.

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1
Department of Medicinal Chemistry, University of Washington, Seattle, WA 98195, USA.

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  • Clin Pharmacol Ther. 2005 Aug;78(2):153.

Abstract

Cytochrome P450 (CYP) 2C8 [corrected] has been a relatively neglected member of the human CYP2C family. Over the period from 2000 through 2003, PubMed searches with the key word CYP2C8 returned only 10% to 15% of the citations obtained for all of the CYP2C enzymes combined. However, in the past year a crystal structure for CYP2C8 has been described, new inhibitors and probe substrates for the enzyme have been in development, the first case study was published linking CYP2C8 genetic polymorphisms to a disease state, and there has been an increasing awareness of the role that CYP2C8 plays in the disposition of therapeutic agents, especially from the pharmacogenetic and drug-drug interaction perspectives. This report discusses baseline characteristics of the enzyme and summarizes recent developments in these areas and their clinical relevance.

PMID:
15900280
DOI:
10.1016/j.clpt.2004.12.267
[Indexed for MEDLINE]
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