Less mortality but more relapses in experimental allergic encephalomyelitis in CD8-/- mice

Science. 1992 May 22;256(5060):1210-3. doi: 10.1126/science.256.5060.1210.

Abstract

Mice lacking in CD8 were generated from homologous recombination in embryonal stem cells at the CD8 locus and bred with the experimental allergic encephalomyelitis (EAE)-susceptible PL/JH-2u through four backcross generations to investigate the role of CD8+ T cells in this model of multiple sclerosis. The disease onset and susceptibility were similar to those of wild-type mice. However, the mutant mice had a milder acute EAE, reflected by fewer deaths, but more chronic EAE, reflected by a higher frequency of relapse. This suggests that CD8+ T lymphocytes may participate as both effectors and regulators in this animal model.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • CD8 Antigens / genetics*
  • CD8 Antigens / metabolism
  • Crosses, Genetic
  • DNA Replication
  • Death
  • Disease Models, Animal
  • Encephalomyelitis, Autoimmune, Experimental / immunology
  • Encephalomyelitis, Autoimmune, Experimental / physiopathology*
  • Female
  • Interleukin-2 / biosynthesis
  • Male
  • Mice
  • Mice, Inbred Strains
  • Mice, Mutant Strains
  • Multiple Sclerosis / immunology
  • Multiple Sclerosis / physiopathology
  • Reference Values
  • T-Lymphocytes / immunology*
  • Thymidine / metabolism

Substances

  • CD8 Antigens
  • Interleukin-2
  • Thymidine