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Philos Trans R Soc Lond B Biol Sci. 2005 Mar 29;360(1455):631-5.

Chromosomal instability and human cancer.

Author information

1
Program for Evolutionary Dynamics, Department of Organismic and Evolutionary Biology, Harvard University, Cambridge MA 02138, USA. michor@fas.harvard.edu

Abstract

Genetic instability is a defining feature of human cancer. The main type of genetic instability, chromosomal instability (CIN), enhances the rate of gross chromosomal changes during cell division. CIN is brought about by mutations of CIN genes, i.e. genes that are involved in maintaining the genomic integrity of the cell. A major question in cancer genetics is whether genetic instability is a cause and hence a driving force of tumorigenesis. A mathematical framework for studying the somatic evolution of cancer sheds light onto the causal relations between CIN and human cancer.

PMID:
15897185
PMCID:
PMC1569472
DOI:
10.1098/rstb.2004.1617
[Indexed for MEDLINE]
Free PMC Article
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