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Philos Trans R Soc Lond B Biol Sci. 2005 Mar 29;360(1455):483-96.

How might cohesin hold sister chromatids together?

Author information

1
IMP (Research Institute of Molecular Pathology), Dr Bohr-Gasse 7, A-1030 Vienna, Austria. knasmyth@imp.univie.ac.at

Abstract

The sister chromatid cohesion essential for the bi-orientation of chromosomes on mitotic spindles depends on a multi-subunit complex called cohesin. This paper reviews the evidence that cohesin is directly responsible for holding sister DNAs together and considers how it might perform this function in the light of recent data on its structure.

PMID:
15897174
PMCID:
PMC1569479
DOI:
10.1098/rstb.2004.1604
[Indexed for MEDLINE]
Free PMC Article

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