Synthesis of 2,4,6-trisubstituted pyrimidines as antimalarial agents

Anu Agarwal; Kumkum Srivastava; S K Puri; Prem M S Chauhan

doi:10.1016/j.bmc.2005.04.061

Synthesis of 2,4,6-trisubstituted pyrimidines as antimalarial agents

Bioorg Med Chem. 2005 Aug 1;13(15):4645-50. doi: 10.1016/j.bmc.2005.04.061.

Authors

Anu Agarwal¹, Kumkum Srivastava, S K Puri, Prem M S Chauhan

Affiliation

¹ Division of Medicinal & Process Chemistry, Central Drug Research Institute, Lucknow 226001, India.

PMID: 15896965
DOI: 10.1016/j.bmc.2005.04.061

Abstract

A series of 2,4,6-trisubstituted-pyrimidines were synthesized and evaluated for their in vitro antimalarial activity against Plasmodium falciparum. Of the 18 compounds synthesized, 14 compounds have shown MIC in the range of 0.25-2 microg/mL. These compounds are in vitro severalfold more active than pyrimethamine.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Antimalarials / chemical synthesis*
Antimalarials / chemistry
Antimalarials / pharmacology*
Molecular Structure
Plasmodium falciparum / drug effects*
Pyrimidines / chemical synthesis
Pyrimidines / chemistry*
Pyrimidines / pharmacology*
Structure-Activity Relationship

Substances

Antimalarials
Pyrimidines