Abstract
A series of 2,4,6-trisubstituted-pyrimidines were synthesized and evaluated for their in vitro antimalarial activity against Plasmodium falciparum. Of the 18 compounds synthesized, 14 compounds have shown MIC in the range of 0.25-2 microg/mL. These compounds are in vitro severalfold more active than pyrimethamine.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Animals
-
Antimalarials / chemical synthesis*
-
Antimalarials / chemistry
-
Antimalarials / pharmacology*
-
Molecular Structure
-
Plasmodium falciparum / drug effects*
-
Pyrimidines / chemical synthesis
-
Pyrimidines / chemistry*
-
Pyrimidines / pharmacology*
-
Structure-Activity Relationship
Substances
-
Antimalarials
-
Pyrimidines