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Bioorg Med Chem. 2005 Aug 1;13(15):4645-50.

Synthesis of 2,4,6-trisubstituted pyrimidines as antimalarial agents.

Author information

1
Division of Medicinal & Process Chemistry, Central Drug Research Institute, Lucknow 226001, India.

Abstract

A series of 2,4,6-trisubstituted-pyrimidines were synthesized and evaluated for their in vitro antimalarial activity against Plasmodium falciparum. Of the 18 compounds synthesized, 14 compounds have shown MIC in the range of 0.25-2 microg/mL. These compounds are in vitro severalfold more active than pyrimethamine.

PMID:
15896965
DOI:
10.1016/j.bmc.2005.04.061
[Indexed for MEDLINE]

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