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Bioorg Med Chem. 2005 Aug 1;13(15):4667-78.

Synthesis and evaluation of 3-aryl piperidine analogs as potent and efficacious dopamine D4 receptor agonists.

Author information

1
Neuroscience Research, Global Pharmaceutical Research and Development, AP9A/L16, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, IL 60064, USA. xueqing.wang@abbott.com

Abstract

A series of 3-aryl piperidine analogs with 2-piperidinoalkylamino or 2-piperidinoalkyloxy fused bicyclic rings were prepared and found to be potent and efficacious human dopamine D4 agonists. The synthesis and structure-activity relationship (SAR) studies that led to the identification of these compounds are discussed.

PMID:
15896964
DOI:
10.1016/j.bmc.2005.04.060
[Indexed for MEDLINE]

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