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J Neurol Sci. 2005 Jun 15;233(1-2):183-98.

Neurofilament phosphoforms: surrogate markers for axonal injury, degeneration and loss.

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Department of Neuroimmunology, Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK.


This review on the role of neurofilaments as surrogate markers for axonal degeneration in neurological diseases provides a brief background to protein synthesis, assembly, function and degeneration. Methodological techniques for quantification are described and a protein nomenclature is proposed. The relevance for recognising anti-neurofilament autoantibodies is noted. Pathological implications are discussed in view of immunocytochemical, cell-culture and genetic findings. With reference to the present symposium on multiple sclerosis, the current literature on body fluid levels of neurofilaments in demyelinating disease is summarised.

[Indexed for MEDLINE]

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