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J Neurol Sci. 2005 Jun 15;233(1-2):183-98.

Neurofilament phosphoforms: surrogate markers for axonal injury, degeneration and loss.

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1
Department of Neuroimmunology, Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK. a.petzold@ion.ucl.ac.uk

Abstract

This review on the role of neurofilaments as surrogate markers for axonal degeneration in neurological diseases provides a brief background to protein synthesis, assembly, function and degeneration. Methodological techniques for quantification are described and a protein nomenclature is proposed. The relevance for recognising anti-neurofilament autoantibodies is noted. Pathological implications are discussed in view of immunocytochemical, cell-culture and genetic findings. With reference to the present symposium on multiple sclerosis, the current literature on body fluid levels of neurofilaments in demyelinating disease is summarised.

PMID:
15896809
DOI:
10.1016/j.jns.2005.03.015
[Indexed for MEDLINE]
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