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Trends Biochem Sci. 2005 May;30(5):250-5.

The mammalian Mediator complex and its role in transcriptional regulation.

Author information

1
Stowers Institute for Medical Research, Kansas City, MO 64110, USA.

Abstract

Mediator is an essential component of the RNA polymerase II general transcriptional machinery and plays a crucial part in the activation and repression of eukaryotic mRNA synthesis. The Saccharomyces cerevisiae Mediator was the first to be defined and is a high molecular mass complex composed of >20 distinct subunits that performs multiple activities in transcription. Recent studies have defined the subunit composition and associated activities of mammalian Mediator, and revealed a striking evolutionary conservation of Mediator structure and function from yeast to man.

PMID:
15896743
DOI:
10.1016/j.tibs.2005.03.002
[Indexed for MEDLINE]

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