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Drug Discov Today. 2005 May 15;10(10):727-34.

Bioinformatic methods for integrating whole-genome expression results into cellular networks.

Author information

1
Department of Pharmacology, University of Florence, Viale Pieraccini 6, 50139 Florence, Italy. duccio.cavalieri@unifi.it

Abstract

Extracting a comprehensive overview from the huge amount of information arising from whole-genome analyses is a significant challenge. This review critically surveys the state of the art methods that are used to connect information from functional genomic studies to biological function. Cluster analysis methods for inferring the correlation between genes are discussed, as are the methods for integrating gene expression information with existing information on biological pathways and the methods that combine cluster analysis with biological information to reconstruct novel biological networks.

PMID:
15896686
DOI:
10.1016/S1359-6446(05)03433-1
[Indexed for MEDLINE]

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