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Cancer. 2005 Jul 1;104(1):126-34.

Lack of benefit of spinal irradiation in the primary treatment of intracranial germinoma: a multiinstitutional, retrospective review of 180 patients.

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1
Department of Radiology, Shinshu University, School of Medicine, Matsumoto, Japan. shikama@hsp.md.shinshu-u.ac.jp

Abstract

BACKGROUND:

The current study assessed the contribution of spinal irradiation to the treatment outcome of patients with intracranial germinoma.

METHODS:

Clinical data from 180 patients with intracranial germinoma, who were treated with radiotherapy and/or chemotherapy from 1980 to 2001, were collected from 6 institutions. The patients' median age was 16 years (range, 1-47 yrs), and the male-to-female ratio was 133:47. Pathologic verification was obtained in 88 patients. A solitary tumor was seen in 129 patients, and multifocal or disseminated tumors were detected in 51 patients. The median tumor size was 2.5 cm (range, 0.6-7.0 cm). Local field and/or whole brain irradiation was performed in 114 patients, and craniospinal irradiation was performed in 66 patients. Fifty-five patients were treated with chemotherapy. The median follow-up time was 89 months (range, 3-297 mos).

RESULTS:

Eight-year overall and event-free survival rates were 91% and 89%, respectively. The 8-year recurrence rates at the primary site, intracranial space, and the spinal space were 1%, 6%, and 6%, respectively. Cox regression analysis showed that spinal irradiation (hazard ratio, 1.050; 95% confidence interval [CI], 0.355-3.170) did not contribute to a favorable event-free survival.

CONCLUSIONS:

Spinal irradiation did not contribute to favorable event-free survival in patients with intracranial germinoma.

PMID:
15895370
DOI:
10.1002/cncr.21169
[Indexed for MEDLINE]
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