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Am J Hum Genet. 2005 Jul;77(1):149-53. Epub 2005 May 13.

Strong association of the Y402H variant in complement factor H at 1q32 with susceptibility to age-related macular degeneration.

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1
Department of Ophthalmology and Visual Sciences, University of Michigan, Ann Arbor, MI, USA.

Abstract

Using a large sample of cases and controls from a single center, we show that a T-->C substitution in exon 9 (Y402H) of the complement factor H gene is strongly associated with susceptibility to age-related macular degeneration, the most common cause of blindness in the elderly. Frequency of the C allele was 0.61 in cases, versus 0.34 in age-matched controls (P<1x10(-24)). Genotype frequencies also differ markedly between cases and controls (chi2=112.68 [2 degrees of freedom]; P<1x10(-24)). A multiplicative model fits the data well, and we estimate the population frequency of the high-risk C allele to be 0.39 (95% confidence interval 0.36-0.42) and the genotype relative risk to be 2.44 (95% confidence interval 2.08-2.83) for TC heterozygotes and 5.93 (95% confidence interval 4.33-8.02) for CC homozygotes.

PMID:
15895326
PMCID:
PMC1226187
DOI:
10.1086/431426
[Indexed for MEDLINE]
Free PMC Article
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