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Autoimmun Rev. 2005 Apr;4(4):224-9. Epub 2004 Dec 30.

Immunogenicity of an inflammation-associated product, tyrosine nitrated self-proteins.

Author information

1
Department of Bioscience and Biotechnology, Okayama University, Tsushima-Naka 3-1-1, Okayama 700-8530, Japan. hit2224@cc.okayama-u.ac.jp

Abstract

To understand the mechanism leading to autoantibody production, it is of importance to reveal how self-components that are otherwise inactive as antigens acquire immunogenicity. One possible mechanism is the generation of structurally modified self-proteins in apoptotic or inflamed tissues. The post-translational modification of proteins might give rise to the generation of new epitopes to which T and B lymphocytes are not rendered tolerant. Among the protein modifications, this review is focussed on the generation and the immunogenicity of self-proteins carrying 3-nitrotyrosine (NT), an inflammation-associated marker. NT-proteins are generated in vivo by nitration with peroxynitrite, which is formed from nitric oxide and superoxide that are released from activated inflammatory cells. Interestingly, many anti-DNA Abs from autoimmune mice have been shown cross-reactive with NT. Analysis of the immunogenicity of NT-carrying self-proteins has revealed that they elicit both humoral and cellular immune responses in mice. Thus, NT-containing epitopes created on self-proteins may serve as a trigger to impair or bypass immunological tolerance.

PMID:
15893716
DOI:
10.1016/j.autrev.2004.11.011
[Indexed for MEDLINE]

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