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Comb Chem High Throughput Screen. 2005 May;8(3):209-17.

Defensins and other antimicrobial peptides: a historical perspective and an update.

Author information

1
Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095-1690, USA. tganz@mednet.ucla.edu

Abstract

Antimicrobial peptides are effectors of innate immunity in phagocytes, body fluids and epithelia. In mammals, defensins, peptides with a characteristic six-cysteine framework, are particularly abundant and widely distributed in various animal species and tissues. The first part of this review provides a historical overview of the ideas that led to the current state-of-the-art in antimicrobial peptides, and the second part is an update on mammalian defensins and their role in host defense to infections.

PMID:
15892623
DOI:
10.2174/1386207053764594
[Indexed for MEDLINE]

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