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J Comput Assist Tomogr. 2005 May-Jun;29(3):320-2.

Proton magnetic resonance spectroscopy and diffusion-weighted imaging of central nervous system whipple disease.

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University of Iowa College of Medicine, Iowa City, IA 52246, USA.


A 72-year-old man presented with a 6-month history of dysphagia, fatigue, 60-lb weight loss, and central nervous system (CNS) deficits. Diffusion-weighted magnetic resonance imaging (MRI) of the brain showed mildly elevated nonrestricted apparent diffusion coefficients in the middle cerebellar peduncles, and magnetic resonance spectroscopy (MRS) showed decreased N-acetylaspartate and creatine with increased choline. Diffusion-weighted MRI and MRS offer noninvasive methods to help evaluate in vivo physiologic changes of CNS involvement in Whipple disease.

[Indexed for MEDLINE]

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