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Microbes Infect. 2005 May;7(5-6):962-7. Epub 2005 Apr 15.

Prime-boost immunisation strategies for tuberculosis.

Author information

1
Centre for Clinical Vaccinology and Tropical Medicine, University of Oxford, Churchill Hospital, Oxford OX3 7LJ, UK. helen.mcshane@ndm.ox.ac.uk

Abstract

Vaccines against intracellular pathogens such as Mycobacterium tuberculosis need to induce strong cellular immune responses. Heterologous prime-boost immunisation strategies induce higher levels of both CD4+ and CD8+ T cells than homologous boosting with the same vector. Recombinant pox-viruses are particularly good at boosting previously primed T cell responses. Using BCG as the priming immunisation in such a heterologous prime-boost strategy is a practical solution, which allows the beneficial effects of BCG in children to be maintained.

PMID:
15890555
DOI:
10.1016/j.micinf.2005.03.009
[Indexed for MEDLINE]

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