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Br J Dermatol. 2005 May;152(5):1051-5.

Treatment of advanced malignant eccrine poroma with locoregional chemotherapy.

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Department of Surgical Oncology, University Hospital, Medical School of Crete, Herakleion, Greece.


Malignant eccrine poroma is a rare disease with approximately 200 cases reported in the literature. Regional cutaneous and systemic metastases are rarely observed and their management has been generally unsuccessful. We report on a case in which topical 5-fluorouracil application and intra-arterial chemotherapy with docetaxel resulted in a histologically confirmed complete response of multiple regional skin metastases for more than 2 years. Despite intravenous administration of docetaxel, slow progression of systemic disease was observed.

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