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Curr Opin Immunol. 2005 Jun;17(3):259-66.

Notch: control of lymphocyte differentiation in the periphery.

Author information

1
Section of Immunology and Infection, Department of Biological Sciences, Imperial College, London, UK. m.dallman@imperial.ac.uk

Abstract

The complexity of the Notch signalling pathway has impeded progress in understanding its precise role in differentiation processes of the mature peripheral immune system. Nevertheless, both B and T lymphocyte responses are undoubtedly influenced by Notch ligation, and defining the mechanisms by which this is achieved remains a challenge. How the innate-adaptive interface and interactions between lymphocytes can be affected, together with the potential of this pathway for therapeutic intervention remain important and stimulating issues.

PMID:
15886115
DOI:
10.1016/j.coi.2005.04.002
[Indexed for MEDLINE]

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