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Curr Opin Immunol. 2005 Jun;17(3):230-6.

Signaling in B cells via Toll-like receptors.

Author information

1
Departments of Internal Medicine, Washington University School of Medicine, St. Louis, Missouri 63110, USA. speng@im.wustl.edu

Abstract

Toll-like receptors (TLRs) and their ligands have emerged as important regulators of immunity, relevant to a wide range of effector responses from vaccination to autoimmunity. The most well-studied ligands of TLRs expressed on B cells include the lipopolysaccharides (for TLR4) and CpG-containing DNAs (for TLR9), which induce and/or co-stimulate B cells to undergo proliferation, class switching and differentiation into antibody-secreting cells. Recent developments in this area include advancements into our understanding of the role of these receptor pathways in B cells, and in particular the relevance of TLR9, which has received substantial attention as both a Th1-like inflammatory immunomodulator and a pathogenic co-stimulator of autoreactive B cell responses.

PMID:
15886111
DOI:
10.1016/j.coi.2005.03.003
[Indexed for MEDLINE]
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