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Parkinsonism Relat Disord. 2005 Jun;11 Suppl 1:S25-9.

Pathogenesis of levodopa-induced dyskinesia: focus on D1 and D3 dopamine receptors.

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Basal Gang, Laboratoire de Physiologie et Physiopathologie de la Signalisation Cellulaire, CNRS UMR 5543, Université Victor Segalen-Bordeaux 2, France.


Involuntary movements, or dyskinesia, represent a debilitating complication of levodopa therapy for Parkinson's disease. Taking advantage of a monkey brain bank constituted to study the pathophysiology of levodopa-induced dyskinesia, we here report the changes affecting D1, D2 and D3 dopamine receptors within the striatum of four experimental groups of non-human primates: normal, parkinsonian, parkinsonian treated with levodopa without or with dyskinesia. We also report the possible role of arrestin and G protein-coupled receptor kinases.

[Indexed for MEDLINE]

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