Accidental blast wave generation and propagation in the surroundings poses severe threats for people and property. The prediction of overpressure maxima and its change with time at specified distances can lead to useful conclusions in quantitative risk analysis applications. In this paper, the use of a computational fluid dynamics (CFD) code CFX-5.6 on dense explosive detonation events is described. The work deals with the three-dimensional simulation of overpressure wave propagation generated by the detonation of a dense explosive within a small-scale branched tunnel. It also aids at validating the code against published experimental data as well as to study the way that the resulting shock wave propagates in a confined space configuration. Predicted overpressure histories were plotted and compared versus experimental measurements showing a reasonably good agreement. Overpressure maxima and corresponding times were found close to the measured ones confirming that CFDs may constitute a useful tool in explosion hazard assessment procedures. Moreover, it was found that blast wave propagates preserving supersonic speed along the tunnel accompanied by high overpressure levels, and indicating that space confinement favors the formation and maintenance of a shock rather than a weak pressure wave.