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Neurology. 2005 May 10;64(9):1644-7.

Effects of chronic lead exposure on 1H MRS of hippocampus and frontal lobes in children.

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  • 1School of Life Science, University of Science and Technology of China, Hefei, Anhui, P. R. China.


The authors performed IQ testing and magnetic resonance spectroscopy on six lead-exposed and six control children. Levels of N-acetyl aspartate (neuronal density and mitochondrial metabolism), creatine + phosphocreatine (phosphate metabolism), and choline (membrane turnover) were decreased in four brain regions (left and right frontal, left and right hippocampus) in lead-exposed children vs controls. The reductions were right frontal > left frontal > hippocampus but were the same bilaterally in the hippocampus.

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