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Biochem Biophys Res Commun. 2005 Jun 17;331(4):1216-21.

L7/Pcp-2-specific expression of Cre recombinase using knock-in approach.

Author information

1
Department of Animal Genomics, Functional Genomics Institute, Mie University Life Science Research Center, 2-174 Edobashi, Tsu, Mie 514-8507, Japan.

Abstract

We report a knock-in mouse expressing Cre recombinase from the translational initiation site (ATG) of the endogenous L7/Pcp-2 gene. The resulting Cre expression matches the pattern of L7/Pcp-2 expression that is restricted to cerebellar Purkinje cells and retinal cells. Moreover, the Cre mouse showed no significant behavioral abnormality. Thus, our novel Cre mouse can be used for generation of Purkinje cells and retinal cell-specific gene expression and/or knockout in mouse using the Cre/loxP system.

PMID:
15883005
DOI:
10.1016/j.bbrc.2005.04.043
[Indexed for MEDLINE]

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