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Urology. 2005 May;65(5):976-9.

Evaluation and management of genital anomalies in two patients with Klinefelter syndrome and review of literature.

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1
Department of Urology, Medical College of Wisconsin and Children's Hospital of Wisconsin, Milwaukee, Wisconsin 53226, USA.

Abstract

OBJECTIVES:

To present the evaluation and management of cryptorchidism and varicocele in patients with Klinefelter syndrome and review the literature. Recent advances in reproductive medicine have resulted in fertility in patients with Klinefelter syndrome. However, cryptorchidism and varicocele can affect the fertility potential on their own.

METHODS:

We present 2 cases and review the literature with an emphasis on the fertility potential.

RESULTS:

Germ cells were present in the testicular biopsy of an infant with cryptorchidism but not in the adolescent with a varicocele. The latter biopsy showed tubular sclerosis.

CONCLUSIONS:

The fertility potential of patients with Klinefelter syndrome and cryptorchidism may be preserved or enhanced by an early orchiopexy. However, the potential benefit of ligation of internal spermatic veins in patients with Klinefelter syndrome and a varicocele warrants further study. Cryopreservation should be considered early in adolescence or adulthood as germ cells become depleted at an accelerated rate after puberty.

PMID:
15882735
DOI:
10.1016/j.urology.2004.12.054
[Indexed for MEDLINE]
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