Format

Send to

Choose Destination
Neuron. 2005 May 5;46(3):377-81.

Developmental mechanisms underlying the generation of cortical interneuron diversity.

Author information

1
Instituto de Neurociencias de Alicante, CSIC and Universidad Miguel Hernández, Campus de San Juan, 03550 San Joan d'Alacant, Spain.

Abstract

GABAergic interneurons are critical components of cortical circuits. However, understanding their function has become extremely challenging because they constitute one of the most diverse groups of cells in the central nervous system. Indeed, cortical GABAergic interneurons are heterogeneous in so many different ways--morphology, molecular profiling, electrical properties--that even attempts to discern what parameters should be used to identify cortical interneuron subtypes have failed to generate broad consensus among experts in the field. The extent to which cortical interneuron diversity emerges during development is largely unknown, but it is likely that insights on how this process takes place may help us understand their role as integrative and synchronizing elements in cortical function. Here, we review recent data on how the large variety of distinct classes of cortical interneurons may arise during development.

PMID:
15882635
DOI:
10.1016/j.neuron.2005.04.020
[Indexed for MEDLINE]
Free full text

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center