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Acta Otolaryngol. 2005 Feb;125(2):130-3.

Substance P upregulates osteoclastogenesis by activating nuclear factor kappa B in osteoclast precursors.

Author information

  • 1Department of Otolaryngology, Catholic University of Daegu School of Medicine, Daegu, South Korea. sjsohn@cu.ac.kr

Abstract

CONCLUSION:

SP upregulates osteoclastogenesis by activating NF-kappaB in osteoclast precursors.

OBJECTIVE:

Osteoclastic bone resorption is a common finding of otitis media with or without cholesteatoma. Factors upregulating osteoclastogenesis are implicated in bone resorption. The aim of this study was to investigate the effect of substance P (SP) on mouse osteoclastogenesis in vitro.

MATERIAL AND METHODS:

The SP dose response was analyzed in a mouse osteoclast culture induced by macrophage colony-stimulating factor and receptor activator for nuclear factor kappa B (NF-kappaB) ligand. Western blot analysis was performed to elucidate the subcellular target of SP in osteoclastogenesis.

RESULTS:

Treatment with SP significantly increased osteoclastogenesis compared to control. SP activated nuclear translocation of NF-kappaB, which is an essential event in osteoclastogenesis in osteoclast precursors (bone marrow macrophages).

PMID:
15880941
[PubMed - indexed for MEDLINE]
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