Format

Send to

Choose Destination
Nat Neurosci. 2005 Jun;8(6):717-9. Epub 2005 May 8.

Laminin stimulates and guides axonal outgrowth via growth cone myosin II activity.

Author information

1
Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, 660 S. Euclid Avenue, St. Louis, Missouri 63110, USA.

Abstract

Guidance cues and signal transduction mechanisms acting at the nerve growth cone are fairly well understood, but the intracellular mechanisms operating to change the direction of axon outgrowth remain unknown. We now show that growth cones integrate myosin II-dependent contraction for rapid, coordinated turning at borders of laminin stripes in response to signals from laminin-activated integrin receptors; in the absence of myosin II activity, outgrowth continues across the borders.

PMID:
15880105
DOI:
10.1038/nn1466
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Nature Publishing Group
Loading ...
Support Center