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Radiother Oncol. 2005 Apr;75(1):70-3. Epub 2005 Mar 16.

Effectiveness and toxicity of single-fraction radiotherapy with 1 x 8 Gy for metastatic spinal cord compression.

Author information

1
Department of Radiation Oncology, University Hospital Hamburg-Eppendorf, D-20246 Hamburg, Germany. rades.dirk@gmx.net

Abstract

Toxicity and functional outcome were evaluated in 199 MSCC-patients irradiated with 1 x 8 Gy. Motor function improved in 54/199 patients (27%). Patients who regained walking ability were 20/78 (26%). Long-term-survivors (> or =12 months) who needed re-irradiation for in-field-recurrence were 19/65 (29%). Acute toxicity was mild, late toxicity not observed. A randomised trial comparing single-fraction RT to multi-fraction RT is mandatory.

PMID:
15878103
DOI:
10.1016/j.radonc.2004.12.013
[Indexed for MEDLINE]

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