Behavioural and cognitive effects of oligofructose-enriched inulin in rats

Br J Nutr. 2005 Apr:93 Suppl 1:S27-30. doi: 10.1079/bjn20041348.

Abstract

The behavioural and cognitive effects of oligofructose-enriched inulin at the doses of 5 and 10 % in the diet, orally ingested daily during 2 weeks, were investigated using a functional observational battery (FOB) and the light extinction test in male Wistar rats. Control rats received a standard diet and were tested in the same test situations. The behavioural effects were assessed 2 d before and 14 d after the beginning of the treatment period and the cognitive effects were investigated after the administration period by lever-pressing activity and learning discrimination using the light extinction test paradigm. In general, the study demonstrated that oligofructose-enriched inulin at 5 % in the diet, and particularly at 10 % in the diet, caused relaxing-like effects, stimulated and increased the general activity and interest of the rats to the test environment. In addition, both doses of oligofructose-enriched inulin showed significant effects on learning discrimination in male rats, in comparison with the control diet. These results suggest that oligofructose-enriched inulin, particularly at the dose of 10 %, improves cognitive performances in the light extinction test and the well-being of male rats using the FOB.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Behavior, Animal*
  • Cognition*
  • Dietary Fiber / administration & dosage*
  • Dietary Fiber / pharmacology
  • Inulin / administration & dosage*
  • Learning
  • Male
  • Oligosaccharides / administration & dosage*
  • Oligosaccharides / pharmacology
  • Rats
  • Rats, Wistar

Substances

  • Dietary Fiber
  • Oligosaccharides
  • oligofructose
  • Inulin