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Br J Haematol. 2005 May;129(4):531-3.

Expression of the Rho-family GTPase gene RHOF in lymphocyte subsets and malignant lymphomas.

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Department of Hematology, University of Utah, 50 North Medical Drive, Salt Lake City, UT 84132, USA.


We have studied the expression of RHOF, a member of the Rho-GTPase family, in an array of lymphoid cells and tissues. Previous microarray studies demonstrated RHOF upregulation in a subset of transformed follicular lymphomas. Real-time quantitative polymerase chain reaction evaluated RHOF expression in lymphocyte subpopulations, and normal and malignant lymphoid tissue. Cells and tissues of B-cell origin expressed higher RHOF levels than their T-cell counterparts. Neoplastic cells and tissues of B-cell origin expressed higher levels of RHOF than their benign cellular counterparts. Relatively elevated levels of RHOF were seen in lymphomas derived from germinal centre origin.

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