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Clin Calcium. 2005 May;15(5):813-8.

[Wnt signaling and bone metabolism].

[Article in Japanese]

Author information

1
Laboratory for Systems Biology and Medicine, Research Center for Advanced Science and Technology, The University of Tokyo.

Abstract

The Wnt family of secreted signaling molecules is essential in embryo development and tumor formation. In addition to the Frizzled family of serpentine receptors, LRP5, a member of the LDL receptor family, was recently shown to function as Wnt receptor. The finding of unique mutations in the human LRP5 gene as a modulator of bone mass establishes the importance of this novel and unexpected role of Wnt/LRP5 signaling in bone development and bone metabolism.

PMID:
15876744
DOI:
CliCa0505813818
[Indexed for MEDLINE]

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