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Phys Med Biol. 2005 May 21;50(10):2351-64. Epub 2005 May 5.

Multiple projection optical diffusion tomography with plane wave illumination.

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  • 1Departments of Radiology and Bioengineering, University of Pennsylvania, Philadelphia, PA 19104 USA.


We describe a new data collection scheme for optical diffusion tomography in which plane wave illumination is combined with multiple projections in the slab imaging geometry. Multiple projection measurements are performed by rotating the slab around the sample. The advantage of the proposed method is that the measured data are more compatible with the dynamic range of most commonly used detectors. At the same time, multiple projections improve image quality by mutually interchanging the depth and transverse directions, and the scanned (detection) and integrated (illumination) surfaces. Inversion methods are derived for image reconstructions with extremely large data sets. Numerical simulations are performed for fixed and rotated slabs.

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