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Gastroenterology. 1992 Jun;102(6):2139-42.

Vitamin E deficiency and impaired cellular immunity related to intestinal fat malabsorption.

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Division of Adult Gastroenterology, Tufts University School of Medicine, Boston, Massachusetts.


This report describes a patient in whom a severe vitamin E deficiency developed secondary to an intestinal malabsorptive disorder. In vivo and in vitro impairment of T-cell function, as well as a polyneuropathy, were observed in conjunction with this vitamin deficiency. Repletion of the vitamin deficiency was associated with marked improvement in the T-cell functions and modest improvement in the neuropathy. Observations in this patient suggest that severe vitamin E deficiency in humans may impair T-cell activity and that correction of the deficient state may reverse these T-cell abnormalities. Further studies will need to be performed to confirm these findings.

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