Format

Send to

Choose Destination
Mol Cell Biol. 2005 May;25(10):4221-8.

Generation and characterization of Rgs4 mutant mice.

Author information

1
CNRS UMR 8542, Department of Biology, Ecole Normale Supérieure, 46 rue d'Ulm, 75005, Paris, France.

Abstract

RGS proteins are negative regulators of signaling through heterotrimeric G protein-coupled receptors and, as such, are in a position to regulate a plethora of biological phenomena. However, those have just begun to be explored in vivo. Here, we describe a mouse line deficient for Rgs4, a gene normally expressed early on in discrete populations of differentiating neurons and later on at multiple sites of the central nervous system, the cortex in particular, where it is one of the most highly transcribed Rgs genes. Rgs4(lacZ/lacZ) mice had normal neural development and were viable and fertile. Behavioral testing on mutant adults revealed subtle sensorimotor deficits but, so far, supported neither the proposed status of Rgs4 as a schizophrenia susceptibility gene (by showing intact prepulse inhibition in the mutants) nor (unlike another member of the Rgs family, Rgs9) a role of Rgs4 in the acute or chronic response to opioids.

PMID:
15870291
PMCID:
PMC1087729
DOI:
10.1128/MCB.25.10.4221-4228.2005
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for HighWire Icon for PubMed Central
Loading ...
Support Center