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Prog Neuropsychopharmacol Biol Psychiatry. 2005 May;29(4):587-91. Epub 2005 Apr 13.

Optimized voxel-based morphometry of gray matter volume in first-episode, antipsychotic-naive schizophrenia.

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Department of Neuroimaging and Interventional Radiology, National Institute of Mental Health and Neurosciences, Hosur road, Bangalore 560029, India.


This study examined gray matter (GM) volume abnormalities in first-episode, antipsychotic-naïve Indian schizophrenia patients. Magnetic resonance images of 18 schizophrenia patients and 18 matched healthy comparison subjects were analyzed by optimized voxel-based morphometry. Schizophrenia patients had significantly smaller global GM and greater global CSF volumes and smaller regional GM volume in superior frontal, inferior frontal, cingulate, post-central, superior temporal and parahippocampal gyri, inferior parietal lobule, insula, caudate nuclei, thalamus and cerebellum. Findings suggest limbic, heteromodal cortical, striatal, thalamic and cerebellar abnormalities in schizophrenia.

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